Refractory angina pectoris is caused by coronary insufficiency which has developed because of an obstructive coronary disease.
Nowadays, such patients can be treated with medication, balloon dilation, stent implants and bypass surgery.
However, some of these patients still suffer from chest pain, even after optimum treatment.
A ratio of 1 to 1.2 is found for endocardial to epicardial blood flow in healthy myocardium.
This deteriorates to 1 to 0.5 in ischaemic myocardium. The ratio improves again from 1 to 1.2 through partial occlusion of the coronary sinus with the reducer.
The reducer manufactured by Neovasc is shaped like an hourglass and is implanted in the coronary sinus using a simple procedure. The reducer is incorporated into the endothelial tissue after 4 - 6 weeks, leaving a narrow passage of 3mm, and can then start to act.
The chest pain that occurs during exercise abates and further improvements occur.