NPi®-200 Pupillometer

The NeurOptics® NPi®-200 pupillometer is used for the objective measurement of pupillary reactivity to assess trends in a patient's neurological status in a comprehensible manner that can be documented and used for potential decisions on therapy.
Pupils are regularly investigated in seriously injured and diseased patients to examine their neurological status. Two main points that are investigated are pupil size and reactivity. Manual pupil measurements with the aid of a penlight or an ophthalmoscope have been shown to be imprecise and not replicable, or inconsistent.
The NeurOptics® NPi®-200 pupillometer puts an end to subjectivity in measurements of pupil size and reactivity.
What measurements are made?
What measurements are made?
  • Maximum pupil size
    ( SIZE )
  • Minimum pupil size
    ( MIN )
  • Change in the pupil in %
    ( CH )
  • Constriction velocity
    ( CV )
  • Maximum constriction velocity
    ( MCV )
  • Latency
    ( LAT )
  • Maximum dilation velocity
    ( DV )
All individual parameters are summarised in the NPi® (neurological pupil index). However, separate trends for each individual parameter can also be returned.
  • Analysis:

    All parameters that have been measured are displayed on the screen. Following multiple sequential measurements, the trend is then displayed on the screen as a curve. The data collected during the examination are stored on the so-called SmartGuard and may easily be extracted and transferred to a table for documentation purposes.
  • How can I prevent the spread of infections if several patients use one device?

    The device can be wiped down using a 50% water / 50 % IPA solution.
    The consumables (SmartGuard) are individually allocated to each patient and can be used for the duration of hospitalisation (storage of 168 measurements per SmartGuard).
  • Can the device be used in children?

    The pupilometer can be used in both children and adults.
  • What is the NPi®?

    The NPi® algorithm allows consistent, objective and quantifiable examination and assessment of pupillary reactivity.
  • How does medication affect pupil reaction and pupil size?

    Most medication that is used affects the absolute basic size of the pupil, but not its reaction.
    Notable exceptions are propofol at high doses and barbiturates, which can render the pupils non-reactive.
  • Effects on NPi®:

    Opiates – no significant effect.
    Propofol – may have an effect at high doses (anaesthetic level).
    Benzodiazepines – no significant effect. NMBs – no effect.
    Dexmedetomidines – potential increase in pupil reaction.
    Barbiturates – reduction in pupil reaction.
  • Effects on constriction velocity (CV)

    As a rule, symmetrical reduction due to opiates, barbiturates and benzodiazepines.

Educational Videos

    Important Clinical Papers

    Interrater Reliability of Pupillary Assessments

    Pupillary Reactivity As an Early Indicator of Increased Intracranial Pressure

    The Use of Automated Pupillometry in Critical Care

    Understanding the Relationship Between the Neurologic Pupil Index and Constriction Velocity Values

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